Influence of probe pressure on diffuse reflectance spectra of human skin measured in vivo

Mechanical pressure superficially applied on the human skin surface by a fiber-optic probe influences the spatial distribution of blood within the cutaneous tissues. Upon gradual load of weight on the probe, a stepwise increase in the skin reflectance spectra is observed. The decrease in the load follows the similar inverse staircase-like tendency. The observed stepwise reflectance spectra changes are due to, respectively, sequential extrusion of blood from the topical cutaneous vascular beds and their filling afterward. The obtained results are confirmed by Monte Carlo modeling. This implies that pressure-induced influence during the human skin diffuse reflectance spectra measurements in vivo should be taken into consideration, in particular, in the rapidly developing area of wearable gadgets for real-time monitoring of various human body parameters

Studying temporal variability of GRS1739-278 during the 2014 outburst

We report a discovery of low-frequency quasi periodic oscillation at 0.3-0.7 Hz in the power spectra of the accreting black hole GRS1739-278 in the hard-intermediate state during its 2014 outburst based on the ${\it NuSTAR}$ and Swift/XRT data. The QPO frequency strongly evolved with the source flux during the NuSTAR observation. The source spectrum became softer with rising QPO frequency and simultaneous increasing of the power-law index and decreasing of the cut-off energy. In the power spectrum, a prominent harmonic is clearly seen together with the main QPO peak. The fluxes in the soft and the hard X-ray bands are coherent, however, the coherence drops for the energy bands separated by larger gaps. The phase-lags are generally positive (hard) in the 0.1-3 Hz frequency range, and negative below 0.1 Hz. The accretion disc inner radius estimated with the relativistic reflection spectral model appears to be $R_{\rm in} < 7.3 R_{\rm g}$. In the framework of the relativistic precession model, in order to satisfy the constraints from the observed QPO frequency and the accretion disc truncation radius, a massive black hole with $M_{\rm BH} \approx 100$M$_\odot$ is required.Comment: 15 pages, 12 figures; accepted for publication in MNRA

Photoacoustic imaging in biomedicine and life sciences

Photo-acoustic imaging, also known as opto-acoustic imaging, has become a widely popular modality for biomedical applications. This hybrid technique possesses the advantages of high optical contrast and high ultrasonic resolution. Due to the distinct optical absorption properties of tissue compartments and main chromophores, photo-acoustics is able to non-invasively observe structural and functional variations within biological tissues including oxygenation and deoxygenation, blood vessels and spatial melanin distribution. The detection of acoustic waves produced by a pulsed laser source yields a high scaling range, from organ level photo-acoustic tomography to sub-cellular or even molecular imaging. This review discusses significant novel technical solutions utilising photo-acoustics and their applications in the fields of biomedicine and life sciences

Stokes-correlometry analysis of biological tissues with polycrystalline structure

Utilizing Stokes-correlometry analysis a new diagnostic approach has been introduced for quantitative assessment of polarization images of histological sections of optically anisotropic biological tissues with different morphological structures and physiological conditions. The developed approach is based on the quantitative assessment of coordinate and phase distributions of the Stokes vector of scattered light. A combined use of statistic, correlation, and fractal analysis is used for resolving variations in optical anisotropy of biological samples. The proposed combined application of the statistical, correlation, and fractal-based evaluates of spatial distributions of `single-point' polarization azimuth, ellipticity, and `two-point' Stokes vector parameters of polarization images of biological tissues histological sections demonstrates a high accuracy (Ac ≥ 90%) in monitoring of optical anisotropy variations within biological tissues

Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry

Observation of temperature-mediated phase transitions between lipid components of the adipose tissues has been performed by combined use of the Abbe refractometry and optical coherence tomography. The phase transitions of the lipid components were clearly observed in the range of temperatures from 24°C to 60°C, and assessed by quantitatively monitoring the changes of the refractive index of 1-to 2-mm-thick porcine fat tissue slices. The developed approach has a great potential as an alternative method for obtaining accurate information on the processes occurring during thermal lipolysis

Combined use of laser Doppler flowmetry and skin thermometry for functional diagnostics of intradermal finger vessels

We introduce a noninvasive diagnostic approach for functional monitoring of blood microflows in capillaries and thermoregulatory vessels within the skin. The measuring system is based on the combined use of laser Doppler flowmetry and skin contact thermometry. The obtained results suggest that monitoring of blood microcirculation during the occlusion, performed in conjunction with the skin temperature measurements in the thermally stabilized medium, has a great potential for quantitative assessment of angiospatic dysfunctions of the peripheral blood vessels. The indices of blood flow reserve and temperature response were measured and used as the primarily parameters of the functional diagnostics of the peripheral vessels of skin. Utilizing these parameters, a simple phenomenological model has been suggested to identify patients with angiospastic violations in the vascular system

RUSSIAN GRAIN FROM SIBERIA: EXPORT POTENTIAL, PRIORITY SALES MARKETS

The study identifies the possibilities of the grain complex of Siberia to supply grain for export. The role of the state and the main regulatory documents of the federal and regional levels, aimed at the development of the grain market and its export from Siberia, have been determined. Using data from the Federal Customs Service of Russia, an analysis of grain exports by regions of Siberia and grain crops for 2017-2019 was carried out. The factors hindering the export of Siberian grain have been warned. The study presents a forecast of grain exports by the regions of Siberia until 2025, as well as its promising directions and priority sales markets. To identify trends in the development of grain exports, the main commodity groups (wheat, rye, barley, oats, buckwheat) were considered. Priority sales markets have been identified, to which supplies should be increased, while solving transport and logistics problems, overcoming tariff and non-tariff barriers

Nanoparticle-free tissue-mimicking phantoms with intrinsic scattering

We present an alternative to the conventional approach, phantoms without scattering nanoparticles, where scattering is achieved by the material itself: spherical cavities trapped in a silicone matrix. We describe the properties and fabrication of novel optical phantoms based on a silicone elastomer polydimethylsiloxane (PDMS) and glycerol mixture. Optical properties (absorption coefficient µa, reduced scattering coefficient µs', and anisotropy factor g) of the fabricated phantoms were retrieved from spectrophotometric measurements (in the 400–1100 nm wavelength range) using the inverse adding-doubling method. The internal structure of the phantoms was studied under a scanning electron microscope, and the chemical composition was assessed by Raman spectroscopy. Composition of the phantom material is reported along with the full characterization of the produced phantoms and ways to control their parameters